The role of autophagy in infection with S. pneumoniae.

Autophagy is a cellular mechanism used to digest old or damaged cellular macromolecules, and the products of such degradation may be recycled to promote cell survival. Autophagy is upregulated by metabolic stresses such as nutrient or growth factor depletion and hypoxia (175).

Thesis full including papers - Karolinska Institutet.

Autophagy is an intracellular catabolic process that involves the sequestration of proteins and whole organelles into specialized cargo vesicles (autophagosomes) and their delivery to lysosomes with subsequent degradation. Autophagy is active at low levels at any time in virtually all cells and can be induced upon a variety of different stimuli.Autophagy is a fundamental catabolic process, which is utilized by nearly every cell and tissue type upon stress exposure and has been shown to contribute to resistance to chemotherapy in a variety of cancers. The subject of this thesis is to shed light on the role of.The role of autophagy in neurodegenerative diseases is an especially controversial topic, with studies on the one hand arguing that autophagy is protecting neurons from death.


TBK1 is a non-canonical IkB kinase, playing a role in autophagy and the innate immune response. Over 150 TBK1 mutations along the entire protein length, predicted to cause TBK1 haploinsufficiency, have been found in patients with ALS and ALS-frontotemporal dementia (FTD).Tusco, Radu (2017) Molecular mechanisms of selective autophagy in innate immunity. PhD thesis, University of Warwick. Teo, Alvin (2017) Detergent-free approach to the studies of bacterial cell division membrane proteins using styrene maleic acid copolymer.

Autophagy Phd Thesis

Oxidative stress and impairment of autophagy can lead to the accumulation and aggregation of damaged proteins, a common feature of most age-related neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease.

Autophagy Phd Thesis

A NOVEL AUTOPHAGY REGULATORY MECHANISM THAT FUNCTIONS DURING PROGRAMMED CELL DEATH. A Dissertation Presented. By. Tsun-Kai Chang. The signatures of the Dissert ation Defense Committee signify completion and approval as to style and content of the Dissertation. Eric H. Baehrecke, Ph.D., Thesis Advisor. Marc R. Freeman, Ph.D., Member of Committee.

Autophagy Phd Thesis

Open Research Online Browse by Thesis Up a level: Export as. PhD thesis. The Open University. Abbott, Dina (1994).. Gain And Loss Of Progranulin Have Opposite Effects On Autophagy. PhD thesis. The Open University. Berridge, Christopher Alan (2010).

Autophagy Phd Thesis

Tahira Anwar, MSc, PhD student. Tahira made her MSc at the University of Rome in 2008. Her MSc thesis dealt with autophagy in tumor cells. Tahira studies the role of Beclin 1 subcellular locatization on autophagosome formation. She is using immunofluorescence staining, Western blotting, and correlative light-electron microscopy in her project.

Autophagy Phd Thesis

Recent research has begun to identify a link between survivin and autophagy, and therefore the aim of this thesis was to clarify the role of survivin in autophagy and to study the reported interaction between survivin and the autophagic protein microtubule-associated protein light chain 3 (LC3).

Newcastle University eTheses: Molecular. - theses.ncl.ac.uk.

Autophagy Phd Thesis

Thesis. Autophagy in hematopoiesis and acute myeloid leukemia. Abstract: Acute myeloid leukemia (AML) develops following oncogenic alterations to hematopoietic stem (HSC) and progenitor cells (HSPCs) in the bone marrow, resulting in dysregulated proliferation of immature myeloid progenitors that interferes with normal hematopoiesis.

Autophagy Phd Thesis

Autophagy is a cellular housekeeping mechanism mediating the degradation of damaged proteins and superfluous organelles. It is a highly sequential process regulated by autophagy related genes (ATGs). Autophagy has also been implicated in the clearance of amyloidogenic proteins including prions.

Autophagy Phd Thesis

This thesis is dedicated to all the people who have encouraged and supported me during the years of my PhD study: to my parents, for their eternal love, endless care and always giving me strength and courage; to my brother, for bringing me all the joy in my childhood, guiding me forward, supporting me whatever the way I have chosen and.

Autophagy Phd Thesis

I certify that this thesis which I now submit for examination for the award of PhD, is entirely my own work and has not been taken from the work of others, save and to the extent that such work has been cited and acknowledged within the text of my work. This thesis was prepared according to the regulations for graduate study by research of.

Autophagy Phd Thesis

BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways Dissertation For attanning the PhD degree of Natural Science submitted to the Faculty of the Johann Wolfgang Goethe University in Frankfurt am Main by Francesca Rapino from Rome, Italy.

Exploration of the role of TBK1 in autophagy and.

Autophagy Phd Thesis

The information gathered in this thesis together with earlier data from other researchers indicates that a dysfunction of autophagy is an essential component in the pathogenesis AMD. This information is needed to develop effective and curative treatments.

Autophagy Phd Thesis

THE CDK INHIBITOR VMY-1-103 INDUCES AUTOPHAGY IN CANCER CELLS AND INHIBITS TUMOR GROWTH IN A MEDULLOBLASTOMA MOUSE MODEL Paul Sirajuddin, B.S. Thesis Advisor: Dr. Chris Albanese, Ph.D. ABSTRACT Cancer is a class of diseases in which cells divide uncontrollably and are able to spread throughout the body.

Autophagy Phd Thesis

A Thesis submitted for the degree of Doctor of Philosophy (PhD) Norwich Medical School School of Medicine and Health Sciences University of East Anglia 2019. Macroautophagy or canonical autophagy, referred to as autophagy hereafter, delivers damaged.

Autophagy Phd Thesis

The autophagy pathway is composed of a number of autophagy related proteins (ATG). One of these, ATG5, can also modulate both the immune system and the cellular death (apoptosis) pathways. Autophagic function declines with age, but whether this leads to Inflamm-aging is unclear.

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