Mechanisms underlying obesity-related insulin resistance.

This thesis investigates the effect of body composition on insulin resistance and the impact of supplementation with nutritional support or carbohydrate treatment. Insulin resistance occurs as a response to a number of stressors, including surgery. However, the mechanism underlying the development of insulin resistance is as yet unclear.

Insulin Resistance Syndrome. - PhD-Dissertations.com.

The Influence of Age and Nutrients on Insulin Sensitivity Carolyn Chee MB ChB, MRCP Thesis submitted to the University of Nottingham for the degree of Doctor of Philosophy December 2015. i Abstract The studies presented in this thesis aimed to investigate the effects of nutritional modulation and age-associated changes on insulin sensitivity. Four separate studies were performed; three of.Polycystic ovary syndrome (PCOS) is a common and complex reproductive and metabolic condition with major health consequences across the lifespan. Insulin resistance is thought to be a key underlying feature of PCOS, but its role in metabolic and reproductive complications associated with the syndrome remains elusive. Therefore, the aim of the thesis was to comprehensively assess the role of IR.Insulin Resistance A Fine-Tuned Interplay Between Diet, Intestinal Microbes and Immunity PhD thesis Benjamin Anderschou Holbech Jensen Academic advisor: Karsten Kristiansen Date of enrollment: 2013.11.01 Date of submission: 2016.09.29 This thesis has been submitted to The PhD School of Science University of Copenhagen. Everything should be as simple as it can be, yet no simpler - Albert.


Insulin resistance (IR) is identified as an impaired biologic response to insulin stimulation of target tissues, primarily liver, muscle, and adipose tissue 1. Glucose uptake by the muscle is impaired which results in a compensatory increase in beta cell insulin production and hyperinsulinemia. The metabolic consequences of insulin resistance can result in hyperglycemia, hypertension.Diabetes and insulin resistance are prominent cardiovascular risk factors and are projected to affect more than 500 million individuals worldwide in the next few decades. Managing hyperglycaemia is not sufficient to reduce the cardiovascular risk that these diseases confer, and there is increasing awareness of insulin resistance as an independent predictor of morbidity and mortality.

Insulin Resistance Phd Thesis

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Insulin Resistance Phd Thesis

The effect of insulin resistance on ageing of skeletal muscle.

Insulin Resistance Phd Thesis

Obesity is a key factor in the development of insulin resistance. Insulin resistance plays a central role in the initiation and progression of type 2 diabetes mellitus and atherosclerosis. Developing novel therapeutic strategies to prevent and treat insulin resistance is therefore important. In humans, the circulating concentration of IGFBP-1 (Insulin like growth factor binding protein-1) has.

Insulin Resistance Phd Thesis

Insulin resistance is a widespread problem that, if not properly managed, can lead to prediabetes and eventually type II diabetes. Thankfully, abundant research suggests that modifying one’s diet to a low-carbohydrate or ketogenic diet can help people lower their insulin to healthy levels and may even help reverse insulin resistance. Nearly all comparative studies on obese subjects suggest.

Insulin Resistance Phd Thesis

Title: The mechanisms underlying free fatty acid-induced hepatic insulin resistance. Degree: Ph.D. Year of Convocation: 2008 Full Name: Kyu Yol Edward Park Department: Physiology. University of Toronto General Abstract Elevated circulating free fatty acids (FFA) cause hepatic insulin resistance; however, the mechanisms for this process are incompletely understood. The objective of the studies.

University of Groningen Glucose Homeostasis and Insulin.

Insulin Resistance Phd Thesis

Defects in microvascular perfusion, which is important for nutrient exchange in skeletal muscle, contribute to insulin resistance associated with obesity and hypertension. One factor that may link this microvascular dysfunction in these conditions is the renin angiotensin system (RAS). The primary objective of this thesis was to address these issues using rat models of obesity and altered RAS.

Insulin Resistance Phd Thesis

The Journal of Insulin Resistance is a peer-reviewed, clinically oriented journal covering advances in disorders of insulin resistance. Articles focus on clinical care and advancing therapy for patients with insulin resistance-related disorders. Insulin resistance includes pathophysiology, management, patient education, and treatment considerations for different patient populations.

Insulin Resistance Phd Thesis

Type 2 diabetes is a disease characterised by a decrease in the sensitivity to insulin. Recently evidence has suggested an involvement of the microvasculature in the development of type 2 diabetes. Microvascular perfusion is increased by insulin and impairment of this response may contribute to muscle insulin resistance by limiting insulin and glucose delivery to skeletal muscle myocytes.

Insulin Resistance Phd Thesis

Introduction: Insulin resistance (IR) and obesity coexist in polycystic ovary syndrome (PCOS) and contribute to increased risk of diabetes and cardiovascular disease. An intrinsic insulin signalling defect is present in skeletal muscle of PCOS and it affects insulin mediated glucose transport in the presence of lipid in vitro studies.

Insulin Resistance Phd Thesis

Obesity is the foremost contributory factor in the progression to type 2 diabetes mellitus (T2DM). Moreover, chronic inflammation, through activation of innate immunity is proposed to link obesity, insulin resistance and T2DM. Adipose tissue, traditionally considered a storage compartment for triglycerides, also functions as an active endocrine organ.

Polycystic Ovary Syndrome, Obesity and Insulin Resistance.

Insulin Resistance Phd Thesis

Insulin resistance is recognised as being a significant risk factor for type 2 diabetes and other metabolic diseases. Yet, insulin resistance measures do not add value to disease risk calculations. 1, 2 People with insulin resistance generally have chronic hyperinsulinaemia to compensate for poor glucose uptake rates. This compensatory hyperinsulinaemia is an independent risk factor for.

Insulin Resistance Phd Thesis

Since the cinnamon have been suggested to improve the insulin resistance in previous studies and taking into account the side effects of metformin, a cinnamon supplement may offer a good and natural alternative to metformin as an insulin-sensitizing agent and thereby improve the ovulation in women with PCOS.3. Rational:The rarely and non-serious reported side effects of cinnamon along with the.

Insulin Resistance Phd Thesis

MOLECULAR BASIS OF INSULIN RESISTANCE IN BARDET BIEDL SYNDROME. by Rachel Diaz Starks A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Molecular and Cellular Biology in the Graduate College of The University of Iowa May 2015 Thesis Supervisors: Associate Professor Kamal Rahmouni.

Insulin Resistance Phd Thesis

UoM administered thesis: Phd. Authors: Alexander Ryan; Abstract. Insulin resistance, a key risk factor for type 2 diabetes, can be defined as when cells fail to respond effectively to insulin. In striated muscle and fat, this manifests as impaired insulin-stimulated glucose uptake due to reduced plasma membrane insertion of the glucose transporter GLUT4. In cell culture models, insulin.

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